Travoprost
Application Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.
Synonyms (+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2; 15(S)-FLU-IPR; 15(S)-FLUPROSTENOL ISOPROPYL ESTER; (+)-FLUPROSTENOL ISOPROPYL ESTER; FLUPROSTENOL ISOPROPYL ESTER; FLU-IPR; 1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate; Travatan; Travatan Z
CAS Number 157283-68-6 | Molecular Formula C26H35F3O6 | Molecular Weight 500.5477
SMILES FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H(O)C[C@H]1O)CC=C/CCCC(=O)OC(C)C)ccc2
StdInChI InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
StdInChIKey MKPLKVHSHYCHOC-AHTXBMBWSA-N
Similar Products Prostaglandin
Available Impurities
Epoxide Derivative
Impurity 1 Epoxide Derivative
Chemical Name: (5Z)-(9S,11R,15S)-9,11,15-Trihydroxy-13,14-epoxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
15-epi Diastereomer
Impurity 2 15-epi Diastereomer
Chemical Name: (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
5,6-trans Isomer
Impurity 3 5,6-trans Isomer
Chemical Name: (5E,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
15-keto derivative
Impurity 4 15-keto derivative
Full Name: (5Z,13E)-(9S,11R)-9,11-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
CAS: 404830-45-1
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
PRODUCT DETAILS
Properties of Travoprost
Appearance Light yellow to almost colorless oil Flash Point 307.5°C Boiling Point 584.8°C at 760 mmHg Density 1.245g/ml Refractive Index 1.547 Description of Travoprost
Standard USP Identification Method TLC, HPLC Assay 96.0%-102% Solubility Soluble in chloroform,ethyl acetate, acetone, practically insoluble in water Specific Rotation +52°～+58°,(C=1 CH2Cl2) Water 1.0% max Related Compounds Epoxide derivative ≤0.40% 15-epi Diastereomer ≤0.1% 5,6-trans Isomer ≤3.5% 15-Keto derivative ≤0.3% Any other impurities ≤0.1% Total other impurity ≤1.0% Related Solvents Isopropanol ≤0.5% Ethyl acetate ≤0.25% n-Hexane ≤0.029% Ethanol ≤0.5% Storage Glass bottle, 2-8°C for shipment and 0 ℃ for long time storage Symbol 
GHS02, GHS07Risk Statements (Europe) 11-36/37/38 Safety Statements (Europe) 16-26-36 Travoprost-CAS-157283-68-6-NMR1
Travoprost-CAS-157283-68-6-NMR2
Travoprost-CAS-157283-68-6-NMR3
Travoprost CAS 157283-68-6 at Watson International Ltd(Sales Link) http://watson-int.com/travoprost-cas-157283-68-6-2/ Travoprost CAS 157283-68-6 at Caming Pharmaceutical Ltd http://caming.com/travoprost-cas-157283-68-6/ Travoprost CAS 157283-68-6 at Watson Noke Scientific Ltd http://watsonnoke.com/travoprost-cas-157283-68-6/
