R-Lipoic Acid (RLA)

Application Lipoic acid (LA), also known as alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound which is widely used as a dietary supplement in some countries marketed as an antioxidant and is available as a pharmaceutical drug in other countries.

Alpha-Lipoic Acid bulk material available today is (R/S) or (+/-) Alpha Lipoic Acid (ALA), meaning it contains a 50/50 mixture of (R-Lipoic) and unnatural (S-Lipoic) Lipoic Acid. The S-Lipoic Acid form, which is not found anywhere in nature, is a byproduct of chemical synthesis. Research indicates that not only does the human body have difficulty absorbing this unnatural version, it may inhibit the most essential properties of the R-Lipoic Acid form!

The “R” form (R Lipoic) is considered the “eutomer” (the biologically superior form) of Alpha Lipoic Acid, since it is identical to that produced by the body. Research indicates R-Lipoic Acid is responsible for most of the beneficial effects attributed to ALA.

While R Lipoic Acid is the obvious choice over Alpha Lipoic Acid, pure R-Lipoic Acid in its “free-acid” form has two major drawbacks: stability and bioavailability. Without special processing, R-Lipoic Acid is highly unstable and difficult to absorb. In fact, pharmacokinetic data reveal that while Alpha Lipoic Acid has a very low absorption rate, unstabilized R-Lipoic Acid is absorbed even worse!

As one of the largest fine chemical developers globally, Watson solved the stability issue by bringing in two other derivatives R(+)-Alpha Lipoic Acid Sodium CAS 176110-81-9 and R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8, being one of the world’s largest purveyor of commercially produced stabilized R-Lipoic Acid materials..

Synonyms (+)-α-Lipoic acid; (±)-1,2-Dithiolane-3-pentanoic acid; (±)-1,2-Dithiolane-3-valeric acid; (R)-(+)-lipoic acid; (R)-6,8-thioctic acid; (R)-lipoate; (R)-lipoic acid; a-Lipoic Acid; AlphaLipogamma; Alphalipoic acid; alphaVibolex; RLA; R-LA; α Lipogamma; α-Vibolex

CAS Number 1200-22-2 | Molecular Formula C8H14O2S2 | Molecular Weight 206.326 | MDL Number MFCD01631142

SMILES C1CSSC1CCCCC(=O)O

StdInChI InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)

StdInChIKey AGBQKNBQESQNJD-UHFFFAOYSA-N

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  • PRODUCT DETAILS

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    Properties of R-Lipoic Acid (RLA)

    AppearanceYellow crystal powder
    Melting Point46~50℃

     

    Description of R-Lipoic Acid (RLA)

    StandardEnterprise standard
    Purity99% min
    Optical Purity99% min
    Specific Optical Rotation+117°~+112°
    Heavy Metals10ppm max
    Loss on Drying0.5% max
    Residue on Ignition0.2% max
    StorageUnder room temperature and away from light
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    RIDADRNONH for all modes of transport
    WGK Germany3
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    None Available

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    R-Lipoic Acid (RLA) CAS 1200-22-2 at Watson International Ltdhttps://www.watson-int.com/r-alpha-lipoic-acid-cas-1200-22-2/
    R-Lipoic Acid (RLA) CAS 1200-22-2 at ULCHO Biochemical Ltdhttps://www.ulcho.com/r-alpha-lipoic-acid-cas-1200-22-2/
    R-Lipoic Acid (RLA) CAS 1200-22-2 at Watson Noke Scientific Ltdhttps://www.watsonnoke.com/r-alpha-lipoic-acid-cas-1200-22-2/
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