• 30 MAY 18
    R-alpha-Lipoic acid tromethamine salt

    R-alpha-Lipoic acid tromethamine salt

    Application Lipoic acid (LA), also known as alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound which is widely used as a dietary supplement in some countries marketed as an antioxidant and is available as a pharmaceutical drug in other countries.

    Alpha-Lipoic Acid bulk material available today is (R/S) or (+/-) Alpha Lipoic Acid (ALA), meaning it contains a 50/50 mixture of (R-Lipoic) and unnatural (S-Lipoic) Lipoic Acid. The S-Lipoic Acid form, which is not found anywhere in nature, is a byproduct of chemical synthesis. Research indicates that not only does the human body have difficulty absorbing this unnatural version, it may inhibit the most essential properties of the R-Lipoic Acid form!

    The “R” form (R Lipoic) is considered the “eutomer” (the biologically superior form) of Alpha Lipoic Acid, since it is identical to that produced by the body. Research indicates R-Lipoic Acid is responsible for most of the beneficial effects attributed to ALA.

    While R Lipoic Acid is the obvious choice over Alpha Lipoic Acid, pure R-Lipoic Acid in its “free-acid” form has two major drawbacks: stability and bioavailability. Without special processing, R-Lipoic Acid is highly unstable and difficult to absorb. In fact, pharmacokinetic data reveal that while Alpha Lipoic Acid has a very low absorption rate, unstabilized R-Lipoic Acid is absorbed even worse!

    As one of the largest fine chemical developers globally, Watson solved the stability issue by bringing in two other derivatives R(+)-Alpha Lipoic Acid Sodium CAS 176110-81-9 and R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8, being one of the world’s largest purveyor of commercially produced stabilized R-Lipoic Acid materials..

    Synonyms 1,2-Dithiolane-3-pentanoic acid, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); 5-(1,2-Dithiolan-3-yl)pentanoic acid – 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); 5-(1,2-Dithiolan-3-yl)pentansäure –2-amino-2-(hydroxymethyl)-1,3-propandiol (1:1) [German]; Acide 5-(1,2-dithiolan-3-yl)pentanoïque – 2-amino-2-(hydroxyméthyl)-1,3-propanediol (1:1) [French]; UNII:V8276EBZ06; 1,2-dithiolane-3-valeric acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); 2-amino-2-(hydroxymethyl)propane-1,3-diol; 5-(3-dithiolanyl)pentanoic acid; 2-azanyl-2-(hydroxymethyl)propane-1,3-diol; 5-(3-dithiolanyl)pentanoic acid; 6,8-THIOCTIC ACID; R-α-Lipoic acid tromethamine salt; R-α-Lipoic acidtromethaminesalt; THIOCTATE TROMETAMOL; tris buffer

    CAS Number 14358-90-8 | Molecular Formula C12H25NO5S2 | Molecular Weight 327.46

    SMILES C1CSSC1CCCCC(=O)O.C(C(CO)(CO)N)O

    StdInChI InChI=1S/C8H14O2S2.C4H11NO3/c9-8(10)4-2-1-3-7-5-6-11-12-7;5-4(1-6,2-7)3-8/h7H,1-6H2,(H,9,10);6-8H,1-3,5H2

    StdInChIKey CCTREOMTIFSZAU-UHFFFAOYSA-N

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