Halofuginone lactate

Application

Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration. Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders. Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.

Synonyms 2-Hydroxypropanoic acid–7-bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]quinazolin-4(3H)-one (1/1); 7-Bromo-6-chloro-3-(3-((3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one 2-hydroxypropanoate; 7-bromo-6-chloro-3-[3-[(3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one 2-hydroxypropanoic acid; 7-Bromo-6-chloro-3-[3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid; 7-bromo-6-chloro-3-[3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid

CAS Number 82186-71-8 | Molecular Formula C19H23BrClN3O6 | Molecular Weight 504.759

SMILES CC(C(=O)O)O.C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O

StdInChI InChI=1S/C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14?,15-;/m1./s1

StdInChIKey GATQERNJKZPJNX-NUNOUFIPSA-N

Similar Products Halofuginone

  • PRODUCT DETAILS

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    Properties of Halofuginone lactate

    AppearanceOff-white to white solid
    SolubilitySoluble in water

     

    Description of Halofuginone lactate

    StandardEnterprise standard
    Assay97% min
    Cis-Halofuginone Lactate2.0% max
    Total Impurities3.0 % max
    Loss on Drying1.0 % max
    ProductivityKG scale or up to MT scale
    StorageUnder room temperature and away from light
    [/vc_nested_tab][vc_nested_tab title=”SAFETY INFORMATION” tab_id=”safety-information”]
    Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
    WGK Germany3
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    Halofuginone lactate IR
    Halofuginone lactate IR
    Halofuginone lactate HPLC
    Halofuginone lactate HPLC
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    Halofuginon Lactate CAS 82186-71-8 at Watson International Limited(Sales Link)https://www.watson-int.com/halofuginon-lactate-cas-82186-71-8/
    Halofuginon Lactate CAS 82186-71-8 at Caming Pharmaceutical Ltdhttps://www.caming.com/halofuginon-lactate-cas-82186-71-8/
    Halofuginon Lactate CAS 82186-71-8 at Watson Noke Scientific Ltdhttps://www.watsonnoke.com/halofuginon-lactate-cas-82186-71-8/
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