Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration. Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders. Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.
Synonyms 2-Hydroxypropanoic acid–7-bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]quinazolin-4(3H)-one (1/1); 7-Bromo-6-chloro-3-(3-((3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one 2-hydroxypropanoate; 7-bromo-6-chloro-3-[3-[(3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one 2-hydroxypropanoic acid; 7-Bromo-6-chloro-3-[3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid; 7-bromo-6-chloro-3-[3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;2-hydroxypropanoic acid
CAS Number 82186-71-8 | Molecular Formula C19H23BrClN3O6 | Molecular Weight 504.759
Similar Products Halofuginone
Properties of Halofuginone lactate
Appearance Off-white to white solid Solubility Soluble in water
Description of Halofuginone lactate
Standard Enterprise standard Assay 97% min Cis-Halofuginone Lactate 2.0% max Total Impurities 3.0 % max Loss on Drying 1.0 % max Productivity KG scale or up to MT scale Storage Under room temperature and away from light Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter WGK Germany 3 Halofuginon Lactate CAS 82186-71-8 at Watson International Limited(Sales Link) https://www.watson-int.com/halofuginon-lactate-cas-82186-71-8/ Halofuginon Lactate CAS 82186-71-8 at Caming Pharmaceutical Ltd https://www.caming.com/halofuginon-lactate-cas-82186-71-8/ Halofuginon Lactate CAS 82186-71-8 at Watson Noke Scientific Ltd https://www.watsonnoke.com/halofuginon-lactate-cas-82186-71-8/