Halofuginone Hydrobromide
Application
Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration. Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders. Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.
Synonyms (±)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide; (±)-trans-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide; 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(±)-4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, hydrobromide (1:1); 7-Brom-6-chlor-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-chinazolinonhydrobromid (1:1); 7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-pipéridinyl)-2-oxopropyl]-4(3H)-quinazolinone, bromhydrate (1:1); 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide; 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)acetonyl)-, monohydrobromide; 7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-2-oxopropyl)quinazolin-4(3H)-one monohydrobromide; 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3H)-one monohydrobromide; 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide
CAS Number 17395-31-2; 64924-67-0 | Molecular Formula C16H18Br2ClN3O3 | Molecular Weight 495.60 | EINECS 241-422-7
SMILES c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)CC3C(CCCN3)O.Br
StdInChI InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H
StdInChIKey SJUWEPZBTXEUMU-UHFFFAOYSA-N
Similar Products Halofuginone
PRODUCT DETAILS
Properties of Halofuginone Hydrobromide
Appearance Off-white to white solid Description of Halofuginone Hydrobromide
Standard Enterprise standard Purity 98% min Single Impurity 1.0% max Total Impurities 2.0 % max Productivity KG scale or up to MT scale Storage Under room temperature and away from light Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter WGK Germany 3 
Halofuginone Hydrobromide CAS 17395-31-2 (64924-67-0) at Watson International Ltd(Sales Link) http://watson-int.com/halofuginone-hydrobromide-cas-17395-31-2/ Halofuginone Hydrobromide CAS 17395-31-2 (64924-67-0) at Caming Pharmaceutical Ltd http://caming.com/halofuginone-hydrobromide-cas-17395-31-2/ Halofuginone Hydrobromide CAS 17395-31-2 (64924-67-0) at Watson Noke Scientific Ltd http://watsonnoke.com/halofuginone-hydrobromide-cas-17395-31-2/
