Cloprostenol isopropyl ester

Application The intermediate of Cloprostenol.
(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF2α.1 (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 x 10-12 M.2 Cloprostenol isopropyl ester is a more lipid soluble form of cloprostenol.

Synonyms ISOPROPYL CLOPROSTENATE; Isopropyl-(5Z)-7-{(1R,2R,3R,5S)-2-[(3R)-4-(3-chlorphenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoat

CAS Number 157283-66-4 | Molecular Formula C25H35ClO6 | Molecular Weight 466.99

SMILES CC(C)OC(=O)CCC/C=CC[C@H]1[C@H](C[C@H]([C@@H]1C=C[C@H](COc2cccc(c2)Cl)O)O)O

StdInChI InChI=1S/C25H35ClO6/c1-17(2)32-25(30)11-6-4-3-5-10-21-22(24(29)15-23(21)28)13-12-19(27)16-31-20-9-7-8-18(26)14-20/h3,5,7-9,12-14,17,19,21-24,27-29H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12?/t19-,21-,22-,23+,24-/m1/s1

StdInChIKey OCNSAYQJDKJOLH-JSMWQALTSA-N

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  • PRODUCT DETAILS

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    Properties of Cloprostenol isopropyl ester

    AppearanceColorless to Yellow Oil

     

    Description of Cloprostenol isopropyl ester

    StandardEnterprise standard
    Identification MethodHNMR, HPLC
    Purity97% min
    Water1.0% max
    Single Impurity0.5% max
    Total Impurities1.5% max
    StorageStore at the 2-8℃
    [/vc_nested_tab] [vc_nested_tab title=”SAFETY INFORMATION” tab_id=”safety-information”]
    Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
    WGK Germany3
    [/vc_nested_tab] [vc_nested_tab title=”SPEC & OTHER DOCCUMENTS” tab_id=”doccuments”] [/vc_nested_tab] [vc_nested_tab title=”OUTBOUND LINKS” tab_id=”OUTBOUND”]
    Cloprostenol isopropyl ester CAS 157283-66-4 at Watson International Ltd(Sales Link)http://watson-int.com/cloprostenol-isopropyl-ester-cas-157283-66-4cloprostenol-isopropyl-ester-cas-157283-66-4/
    Cloprostenol isopropyl ester CAS 157283-66-4 at Caming Pharmaceutical Ltdhttp://caming.com/cloprostenol-isopropyl-ester-cas-157283-66-4/
    Cloprostenol isopropyl ester CAS 157283-66-4 at Watson Noke Scientific Ltdhttp://watsonnoke.com/cloprostenol-isopropyl-ester-cas-157283-66-4/
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